Tysabri 300 mg Injection | 15ml in 1 vial

Introduction of Tysabri 300 mg Injection

​Tysabri 300 mg Injection is a monoclonal antibody used to treat two conditions: multiple sclerosis, a disease of the central nervous system, and Crohn's disease, an inflammatory bowel disease, typically in adult patients. By interfering with specific actions of the body's immune system, this drug selectively targets and eliminates certain cells, potentially protecting healthy cells from damage. However, its safety and efficacy in people under the age of 18 have yet to be established.

While Tysabri 300 mg Injection can be beneficial, it can also cause several side effects, including headache, fatigue, urinary tract infections, joint pain, lung infections, depression, pain in the limbs, diarrhoea, vaginitis, rash, nose and throat infections, nausea and abdominal discomfort. If any of these effects persist or bother you, consult your doctor.

Before starting treatment with Tysabri 300 Injection, it is important to tell your doctor if you have a medical condition that weakens your immune system (e.g. HIV/AIDS, leukaemia, lymphoma, organ transplant), or if you have any new or worsening medical problems that persist for several days. In addition, if pregnancy is being considered, it's important to discuss the potential risks, as Tysabri 300 mg Injection can cause low platelet levels and, in some cases, anaemia. Breastfeeding mothers should also consult their doctor about the safest breastfeeding practices while using Tysabri 300 mg, as it can pass into breast milk.

Patients taking Tysabri 300 mg Injection should be vigilant for signs of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection, and discuss any concerns with their doctor immediately.

The administration of Tysabri 300 mg Injection is usually done intravenously under medical supervision in a hospital or clinic. Your healthcare provider will determine the appropriate timing and dosage, which may vary depending on your condition. Following your doctor's instructions and continuing treatment for the full prescribed duration is important. It's also important to tell your healthcare provider about all the medicines and supplements you are taking, especially those that affect the immune system, to ensure safe use of Tysabri 300 mg.

Uses of Tysabri 300 mg Injection

Multiple sclerosis (MS): Tysabri 300 mg Injection is prescribed for managing multiple sclerosis (MS), a condition affecting the brain and spinal cord. In MS, the body's immune system mistakenly targets and damages the protective covering (myelin) of nerves, resulting in symptoms like vision impairment, pain, fatigue, and coordination issues.

Crohn’s disease: Tysabri 300 mg Injection is used to treat Crohn's disease, a form of chronic inflammatory bowel disease (IBD) impacting various sections of the digestive system, from the mouth to the anus. This condition involves the immune system attacking the digestive tract lining, leading to inflammation, ulceration, and thickening of the bowel wall.

Benefits of Tysabri 300 mg Injection

Multiple sclerosis (MS) is a condition that affects the brain and spinal cord, characterized by the immune system mistakenly attacking the protective covering of nerves, known as myelin. This assault leads to a variety of symptoms including vision problems, pain, fatigue, and difficulties with coordination. Tysabri 300 mg Injection is designed to intervene by suppressing the immune system, thus slowing down the progression of the disease. Reducing inflammation around the damaged nerves helps halt further deterioration and stabilizes the immune response. This medication also aids in enhancing muscle strength, thereby improving mobility and boosting patients' confidence, ultimately contributing to an improved quality of life.

Crohn's disease, on the other hand, is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation anywhere along the digestive tract, from the mouth to the anus. In this condition, the immune system attacks the lining of the digestive tract, resulting in inflammation, ulceration, and thickening of the bowel wall. Tysabri 300 mg Injection functions by selectively binding to specific immune cells, preventing their migration across both the blood-brain barrier and the inflamed intestinal lining. This mechanism effectively reduces inflammation in the affected regions, offering relief from symptoms associated with Crohn's disease.

Side Effects of Tysabri 300 mg Injection

As with any medication, Tysabri 300 mg Injection may elicit side effects, which typically resolve as your body acclimates to the treatment and do not necessitate immediate medical intervention. However, if these side effects persist or cause concern, it's advisable to seek guidance from your doctor for further evaluation and management.

Most Common Side Effects of Tysabri 300 mg Injection

• Diarrhoea
• Vaginitis
• Rash
• Nose and throat infections
• Nausea, 
• Stomach area pain.​
  

Common Side Effects of Tysabri 300 mg Injection

• Headache
• Feeling tired 
• Urinary tract infection 
• Joint pain
• Lung infection
• Depression
• Pain in your arms or legs
  

How to Use Tysabri 300 mg Injection?

Tysabri 300 mg Injection is typically administered intravenously in a hospital or clinic under the supervision of a doctor or nurse. Your healthcare provider will determine the appropriate timing for the injection, so it's important to adhere to their guidance. The dosage and frequency of administration depend on the specific condition being treated. Additionally, your doctor may recommend complementary medications as part of your overall treatment plan. It's essential to continue taking this medication for the duration prescribed by your healthcare provider.

How Tysabri 300 mg Injection Works?

In multiple sclerosis, the immune system attacks the myelin, a fatty substance that surrounds and protects nerve fibres in the brain and spinal cord. This leads to inflammation and damage to the myelin and nerve fibres. By preventing immune cells from crossing the blood-brain barrier, Tysabri 300 Injection reduces inflammation in the central nervous system, which can help slow down the progression of the disease and reduce the frequency and severity of relapses.

In Crohn's disease, the immune system attacks the lining of the digestive tract, leading to inflammation, ulcers, and thickening of the bowel wall. By preventing immune cells from crossing the intestinal lining, Tysabri 300 mg Injection reduces inflammation in the affected areas and can help improve symptoms and reduce the need for hospitalization.

Safety Advices Tysabri 300 mg Injection

Alcohol

Unsafe

Kidney

Use with Caution

Pregnancy

Unsafe

Breastfeeding

Unsafe

Driving

Unsafe

Liver

Use with Caution

References

1. Tysabri 300 Mg Concentrate For Solution For Infusion, Product Leaflet

2. Tysabri 300mg Injection, Avaliable Form

3. Tysabri (natalizumab) Injection, For Intravenous Use, Product Leaflet

4. Natalizumab, Drugs.com, Avaliable Form