Eligard Depot 45 mg Injection | 1 Vial

Introduction of Eligard Depot 45 mg Injection

​​Eligard Depot 45 mg Injection is a gonadotropin-releasing hormone (GnRH) agonist. It is used in the treatment of conditions related to hormone regulation, particularly those associated with the reproductive system. It is also used to treat prostate cancer in men, breast cancer and endometriosis in women and precocious puberty (early puberty) in children. The safety and effectiveness of Eligard Depot 45 mg Injection have not been established in pediatric patients less than 1 year old.

​​Eligard Depot 45 mg Injection may cause some common adverse effects including acne/seborrhea, vaginitis/vaginal bleeding/vaginal discharge, pain, rash including erythema multiforme, headache, and vasodilation, injection site pain, increased weight, headache, altered mood, and injection site swelling. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7–12 weeks, inform your doctor if menstrual bleeding continues even during the treatment.

​​People who have experienced any type of allergic reaction to Eligard Depot 45 mg Injection or similar drugs should not take Eligard Depot 45 mg. Females who are or may be pregnant or have undiagnosed uterine bleeding should not receive Eligard Depot 45 mg Injection. Seizures have been observed in patients taking Eligard Depot 45 mg Injection patients who have a history of seizures or conditions related to seizures or in patients who are taking medications that are connected to seizures. Seizures have also been reported in patients without any of these conditions.

​​Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoking, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. 

Eligard Depot 45 mg Injection is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.​

Uses of Eligard Depot 45 mg Injection

​​Endometriosis: Eligard Depot 45 mg Injection is used for the management of endometriosis, including pain relief and reduction of endometriotic lesions.

​​Uterine Fibroids: Eligard Depot 45 mg Injection is used before fibroid surgery to improve anaemia due to vaginal bleeding from fibroids for patients in whom 3 months of hormonal suppression is deemed necessary. The duration of therapy with Eligard Depot 45 mg Injection is limited to 3 months. The symptoms associated with fibroids will return after stopping therapy.

​​Advanced Prostate Cancer: Eligard Depot 45 mg Injection is used for the treatment of advanced prostate cancer.

​​Central Precocious Puberty (CPP): Eligard Depot 45 mg Injection is used for the treatment of children with central precocious puberty (CPP). It is not known if Eligard Depot 45 mg is safe and effective in children less than 1-year-old.​

Benefits of Eligard Depot 45 mg Injection

​​In Treatment of Endometriosis
​​Endometriosis is a condition where tissue like the lining of the womb starts to grow in other places. The main symptoms include pain in your lower stomach or back, period pain, pain during and after sex, constipation, diarrhoea and feeling sick. It can also make it difficult to get pregnant. Eligard Depot 45 mg Injection acts by preventing the lining of your womb and any endometriosis tissue from growing too quickly. This will help relieve the symptoms you may have. This medicine needs to be taken regularly to be effective and you may need other medicines or procedures to help control endometriosis.

​​In Treatment of Uterine fibroids
​​Uterine fibroids are non-cancerous growths of the uterus that often appear during the childbearing years. Eligard Depot 45 mg can help control the symptoms associated with uterine fibroids such as excessive menstrual bleeding, and lower back pain, and also reduces the size of the existing fibroids. It blocks the action of the enzyme responsible for the growth of the broids. As a result, they decrease in size and also stop growing further.

​​In Treatment of Advanced prostate cancer
​​The prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperm in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Eligard Depot 45 mg Injection may decrease or stops the growth of cancer cells by decreasing the amount of testosterone (a natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

​​In Treatment of Precocious puberty (premature puberty)
​​When puberty (change of a child’s body to adult structure and size) begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Eligard Depot 45 mg Injection helps delay this early onset of adulthood and limits the onset of precocious puberty. However, this medicine is given by a doctor and should not be self-administered. Follow your doctor’s instructions carefully for the most benefit.​

Side Effects of Eligard Depot 45 mg Injection

​​​​​​Like all medication, Eligard Depot 45 mg Injection may cause some side effects. If you experience any of these side effects contact your doctor as soon as possible. Your doctor may be able to suggest ways to manage or reduce the severity of these side effects.​​​​​

Most Common Side Effects of Eligard Depot 45 mg Injection

• Nausea
  
• Vomiting
• Dry mouth
• Confusion
• weakness
• Bone pain
• Dizziness
• Slow Speech
• Feeling thirsty
• ​Constipation
• Weight Fluctuation
• Muscle pain
• Runny nose
• Abdominal Pain
• Acne
• Nervousness
• Difficulty in remembering things
• Spotting
• Irregular menstruation
• Vaginal discharge

Common Side Effects of Eligard Depot 45 mg Injection

• Hematuria
  
• Fainting
• Seizures
• Blurred Vision
• Difficult Breathing
• Severe Headache
• ​Decreased Sexual Desire
• Change in Breast Size
• Hot flashes
• Intense sweating
• Tingling sensation on feet and palms
• Feeling Uneasiness
• Decreased Testicles size​

How to Use Eligard Depot 45 mg Injection?

​​​Your healthcare professional or nurse will give you this medicine. Kindly do not self-administer.​​

How Eligard Depot 45 mg Injection Works?

Eligard Depot 45 mg Injection is an agonist of Gonadotropin-releasing hormone receptor, which leads to suppression of Gonadotrope secretion of Luteinizing Hormone and Follicle stimulating hormone. Initially, it increases the level of Estrogen and Testosterone irrespective of sex. But a continuation of this therapy decreases the level of Testosterone in males and estrogen in females.

Safety Advices Eligard Depot 45 mg Injection

Alcohol

Unsafe

Breastfeeding

Unsafe

Pregnancy

Unsafe

Driving

Unsafe

Liver

Use with Caution

Kidney

Use with Caution

References

1. Leuprolide Acetate for Depot Suspension, 3-month Formulation, Abbott Laboratories, Product Leaflet

2. Lupron Depot-ped (Leuprolide Acetate for Depot Suspension), for Intramuscular Use, Abbvie Inc. Product Leaflet