Zoldonat 4 mg Injection | 4 mg in 1 Vial

Introduction of Zoldonat Injection

Zoldonat 4 mg Injection is used for treating Paget's disease, a disorder that affects the replacement of old bone with new, in both men and women. Zoldonat Injection is indicated for use in males with osteoporosis and postmenopausal women with the same condition. 

Zoldonat 4 mg Injection helps lower calcium levels in cancer patient's blood. Interacting with calcium phosphate crystals, slows down the development of bone components, reducing the likelihood of fractures and enhancing bone density. Furthermore, it hinders the growth of metastatic cancer cells.

Zoldonat Injection may cause side effects such as headache, nausea, fatigue, anaemia, bone pain, constipation, fever, vomiting, breathlessness, and more. It can also weaken your immune system. Consult your doctor regarding these side effects and make sure to drink plenty of water and avoid smoking or drinking alcohol during treatment. Please inform your doctor of any other medications you are taking as they may affect the treatment.

The safety and efficacy of Zoldonat for treating hyperparathyroidism or nontumor-related hypercalcemia have not been established. Similarly, the safety and effectiveness of Zoldonat 4 mg Injection in children aged 1 to 17 have not been confirmed.

Patients receiving Zoldonat Injection treatment should not also receive Reclast. Additionally, Zoldonat 4 Injection should not be administered to patients already receiving Zometa, as both contain zoledronic acid.

Zoldonat Injection will be given through intravenous infusion in a hospital clinic. The administration of Zoldonat 4 mg is a slow process, taking approximately 15 minutes to complete. The number of doses will depend on the reason for the prescription, with many patients only needing a single dose, but repeat doses may be necessary for those with osteoporosis or specific cancers.

Uses of Zoldonat Injection

Osteoporosis: Zoldonat 4 mg Injection is used to treat osteoporosis, a disorder that weakens bones, making them more susceptible to fractures. This is caused by the loss of bone density and the degeneration of bone tissue architecture. Although osteoporosis is more prevalent in postmenopausal women, it can also affect men.

Hypercalcemia: Zoldonat 4 Injection is used in treating hypercalcemia, a medical condition characterized by an excessive amount of calcium in the blood. Symptoms of hypercalcemia can include fatigue, weakness, headache, nausea, vomiting, constipation, dehydration, and confusion.

Benefits of Zoldonat Injection

Zoldonat Injection is a bisphosphonate medication that offers several benefits. Zoldonat helps prevent fractures and increase bone density in patients with osteoporosis, as well as preventing hypercalcemia related to certain cancers. Additionally, Zoldonat 4 Injection slows down the progression of Paget's disease and eases associated symptoms. Zoldonat 4 mg Injection makes the bones stronger and also helps to make them denser which reduces the tendency of bone fracture.

Side Effects of Zoldonat Injection

​​​​​​Like all medication, Zoldonat 4 mg Injection may cause some side effects. If you experience any of these side effects contact your doctor as soon as possible. Your doctor may be able to suggest ways to manage or reduce the severity of these side effects.​

Most Common Side Effects of Zoldonat Injection

• Headache
• Back pain
• Musculoskeletal pain
• Heartburn
• Diarrhea
• Nausea
• Breathlessness
• Fatigue
• Constipation
• Bone pain
• Vomiting
• Fever
• Anemia
• Conjunctivitis
• Low phosphate

Common Side Effects of Zoldonat Injection

• Severe kidney problems
• Low calcium levels in the blood

How to Use Zoldonat Injection?

Zoldonat Injection will be given through intravenous infusion in a hospital clinic. The administration of Zoldonat 4 mg is a slow process, taking approximately 15 minutes to complete. The number of doses will depend on the reason for the prescription, with many patients only needing a single dose, but repeat doses may be necessary for those with osteoporosis or specific cancers. Drink plenty of water to stay hydrated during this treatment.

How Zoldonat Injection Works?

Zoldonat Injection is a bisphosphonate drug that stops the erosion of bones. This action reduces the risk of fractures in conditions like osteoporosis and cancers that have spread to the bones. Zoldonat Injection binds to the surface of bones and decreases the activity of cells known as osteoclasts, which degrade bones. This results in a decrease in the release of calcium into the bloodstream, aiding in the strengthening of bones and reducing fracture risk.

Safety Advices Zoldonat Injection

Alcohol

Unsafe

Pregnancy

Unsafe

Breastfeeding

Unsafe

Driving

Unsafe

Kidney

Use with Caution

Liver

Use with Caution

References

1. Zoledronic Acid- Zoledronic Acid Injection, Solution, Laboratorios Grifols, Sa, [revised: 8/2021], Product Leaflet 

2. Zometa 4 Mg Powder And Solvent For Solution For Infusion, Laboratori Fundació Dau, Product Leaflet 

3. Zoledronic Acid Injection For Intravenous Use, Sagent Pharmaceuticals, Inc. Product Monograph 

4. Zoledronic Acid, National Institutes Of Health, Available Form 

5. Zoledronic Acid, Drugs.com, Available Form​