Oncofluor 250 mg Injection | 250 mg in 1 Vial

Introduction of Oncofluor 250 mg Injection

Oncofluor 250 mg Injection is a cancer drug. It is used alone or in combination with other medicines for the treatment of malignant tumors, particularly of the breast, colon or rectum, and for the treatment of stomach, primary liver, pancreatic, uterine (particularly cervical), ovarian and bladder cancer

Oncofluor 250 mg Injection may cause some common adverse effects, including infections, increased chance of getting infections and/or delayed wound healing due to low white blood cells, anaemia (reduction in red blood cells), difficulty breathing, irregular heart rhythm, diarrhoea, (loss of appetite), inflammation of the lining of the mouth, throat, intestines, rectum, or anus, hair loss (reversible, especially in women), redness, swelling, or pain in the palms and/or soles of the feet, tiredness, general feeling of being unwell, weakness.

Oncofluor 250 mg Injection can reduce the number of blood cells in your blood (decrease red blood cells and white blood cells), which can increase susceptibility to infection. You will need regular blood checks to monitor your heart, liver and uric acid.

Oncofluor 250 mg Injection is not recommended if you are allergic to any of the other ingredients used to make this medicine. Oncofluor Injection is also not recommended in people with weak immune systems (poor nutrition), bone marrow damage from radiation therapy, serious infections, breastfeeding, and if you have taken riverine, and similar drugs (antivirals) within 4 weeks.  If these conditions exist, consult your doctor before taking this Oncofluor 250 mg. Contact your doctor immediately if you experience signs or symptoms of confusion, disorientation, altered mental status, problems with balance or coordination, or blurred vision.  These may indicate encephalopathy which, if left untreated, can lead to coma and may result in death.

Before taking this Oncofluor 250 mg Injection, tell your doctor your past and present medical history, including if you have heart disease, liver or kidney problems, or are taking medicines for infections or other medical complications.  Many other drugs may interact with this drug, so be sure to tell your doctor if you are taking any other prescription or over-the-counter drugs, herbs, or vitamins. This treatment isn't recommended at some unspecified time within the future of pregnancy or at the same time as breastfeeding. To avoid pregnancy, both men and women need to use effective contraception during treatment. It is advised to stop smoking and drinking alcohol while taking this medicine as it may affect the way this medicine works.

Oncofluor 250 mg Injection will be administered by a doctor or nurse in a hospital or clinic setting. Your doctor will decide what dose and how often you should take it. This will be a function of what you are being treated for and may differ from time to time. You should take this medicine exactly as your doctor or health care professional advises. If you take it the wrong way, or if you take too much, you can get severe side effects. It may take several weeks or months before you see or feel the benefits of this medicine. Do not stop taking this medicine unless your doctor tells you to. Alcohol may increase the risk of liver damage, so you should avoid drinking alcohol. This medicine should not be self-administered.

Uses of Oncofluor 250 mg Injection

Breast cancer: Oncofluor 250 mg Injection is utilized for the management of breast cancer. Indications and manifestations of breast cancer encompass the presence of a lump or thickening in the breast or underarm region, alterations in breast size or shape, nipple discharge or inversion, and changes in the skin like redness or dimpling. Nevertheless, some individuals with breast cancer may not exhibit any symptoms at all.

Colon or rectal cancer: Oncofluor Injection is employed for the treatment of colon cancer, also referred to as colorectal cancer, which is a form of cancer that affects the colon or rectum.  Symptoms may involve modifications in bowel habits, the presence of blood in the stool, abdominal pain, and unintentional weight loss.

Gastric cancer: Oncofluor 250 mg Injection is utilized for the management of gastric cancer, also known as stomach cancer, which is a type of cancer that develops in the lining of the stomach.  Symptoms of gastric cancer may include abdominal pain, nausea and vomiting, difficulty swallowing, unintentional weight loss, and the presence of blood in the stool. However, some individuals with early-stage gastric cancer may not experience any symptoms.

Liver cancer: Oncofluor 250 mg is employed for the treatment of liver cancer. Symptoms of liver cancer may encompass abdominal pain, nausea and vomiting, unexplained weight loss, jaundice (yellowing of the skin and eyes), and swelling in the abdomen.

Pancreatic cancer: Oncofluor Injection is utilized for the treatment of pancreatic cancer, which is a type of cancer that originates in the pancreas. Symptoms of pancreatic cancer may include abdominal pain, jaundice (yellowing of the skin and eyes), unexplained weight loss, and alterations in bowel habits.

Cervical cancer: Oncofluor 250 mg Injection is employed in the treatment of cervical cancer, which is a type of cancer That develops inside the cervix, the decrease of a part of the uterus that connects to the vagina. It is commonly caused by the human papillomavirus (HPV), a sexually transmitted infection. Symptoms of cervical cancer may include abnormal vaginal bleeding, pelvic pain, pain during sexual intercourse, and vaginal discharge with an unpleasant odour.

Ovarian cancer is a form of cancer that originates in the ovaries, the female reproductive organs responsible for producing eggs and female hormones. Oncofluor 250 mg Injection is utilized to treat this specific type of cancer. Common symptoms of ovarian cancer include abdominal pain, bloating, difficulty eating or feeling full quickly, frequent urination, and changes in bowel habits.

Bladder cancer, on the other hand, is a type of cancer that develops in the bladder, a hollow organ located in the lower abdomen responsible for storing urine. Oncofluor 250 mg Injection is employed in the treatment of bladder cancer. Symptoms of bladder cancer may include blood in the urine, frequent urination, pain or burning during urination, and lower back pain.

Benefits of Oncofluor 250 mg Injection

Oncofluor 250 mg Injection may help to treat certain types of cancer, such as breast, lung, bowel, rectal and other cancers. It may be used alone or in combination with other medicines to treat cancer in different parts of the body. Oncofluor 250 mg kills or stops the growth of cancer cells and also prevents cancer cells from multiplying. It is a strong and very toxic medicine, and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol during this treatment and drink plenty of water to stay hydrated.

Side Effects of Oncofluor 250 mg Injection

Most side effects do not require medical attention and will go away as your body gets used to the medicine. Tell your doctor or health care professional if any of these symptoms get serious or if they bother you for a long time.

Most Common Side Effects of Oncofluor 250 mg Injection

• Loss of appetite
• Tiredness
• Weakness
• Headache
• Hair Loss
• Blisters on feet/fingers

Common Side Effects of Oncofluor 250 mg Injection

• Decreased red blood cells
• Decreased white blood cells
• Decreased platelets count
• ​Vomiting
• Nausea
• Itching
• Fever
  

How to Use Oncofluor 250 mg Injection?

Oncofluor 250 mg Injection is given as a liquid (solution) that is slowly injected (infused) into a vein in your body by a healthcare professional, doctor or nurse. The dosage schedule or length of treatment depends on how well your body responds to the medicine, what other medicines you are taking, and what type of cancer you have. If you experience any serious side effects while being treated with Oncofluor Injection, tell your doctor immediately.

How Oncofluor 250 mg Injection Works?

Oncofluor 250 mg Injection is thought to be the binding of the folate cofactor, N5-1-methylenetetrahydrofolate and of the drug, to synthase to form a covalently bound ternary complex. It works by interfering with the growth of DNA camp; and RNA synthesis (genetic material) of the cancer cells. As a result, it stops the multiplication and new development of the cancer cells and eventually kills them.

Safety Advices Oncofluor 250 mg Injection

Alcohol

Unsafe

Kidney

Safe

Liver

Use with Caution

Pregnancy

Unsafe

Breastfeeding

Unsafe

Driving

Unsafe

References

1. Fluorouracil 25 mg/ml Injection, Hospira UK Limited, Product Leaflet

2. Fluorouracil, Accord Healthcare Pty Ltd, Product Leaflet

3. Fluorouracil Ebewe 50 mg/mL solution for injection, Novartis New Zealand Limited, Product Leaflet

4. Fluorouracil 50 mg/ml Injection, Hospira UK Ltd, Product Leaflet