Introduction of Xgeva 120 mg PFS

• Xgeva 120 mg PFS contains denosumab, which belongs to the group of medicines called monoclonal antibodies. Xgeva 120 mg PFS is used to treat adults with advanced cancer to prevent serious complications caused by bone metastasis (e.g., fractures, pressure on the spinal cord, radiation therapy, or surgery). Xgeva PFS Injection is also used to treat giant cell tumors of the bone, which cannot be treated by surgery, especially in adults whose bones have stopped growing. Symptoms include a visible mass and bone joints being affected (fracture, fluid buildup, limited movement, swelling, and pain in the joints).
  
  Denosumab 120 mg Injection may cause some common side effects of this medicine, including pain in extremity, musculoskeletal pain, nerve pain, urinary tract infection, constipation, and rash. Talk to your doctor if any of these side effects do not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.
  
  Anti-bone loss injection Xgeva is not recommended for use in patients having hypocalcemia (low calcium levels in blood) and having unhealed wounds from oral surgery. Before receiving Denosumab 120 mg Injection, inform your doctor if you have any problems with your mouth or teeth (poor dental health, gum disease, etc.). Xgeva PFS Injection is not recommended among women who are pregnant. Consult your doctor for advice before receiving Xgeva 120 mg Prefilled Syringe if you are breastfeeding. Anti-bone loss injection Xgeva is not recommended for children and adolescents under 18 years of age except for adolescents with giant cell tumors of the bone whose bones have stopped growing. The most common side effects of receiving Xgeva 120 mg PFS are pain in the bones, joints, and muscles; shortness of breath; diarrhea; hypophosphatemia (low phosphate level); and excessive sweating.
  
  Denosumab 120 mg Injection can be administered to you subcutaneously (under the skin) by a doctor or nurse. You should also take calcium and vitamin D supplements while being on treatment with Xgeva PFS Injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
  

Uses of Xgeva 120 mg PFS

• Denosumab 120 mg Injection is used in the treatment of the following condition:

  • Osteoporosis
  • Bone loss due to hormonal therapy in breast or prostate cancer
  • Multiple myeloma (cancer affects plasma cells in the bone marrow)
  • Bone metastases (cancer that spreads to bone)
    

Benefits of Xgeva 120 mg PFS

• Xgeva PFS Injection binds to RANKL, a protein that is essential for the formation, function, and survival of osteoclasts (the cells responsible for bone resorption). It inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength of the bone. Along with this treatment, your doctor might ask you to make certain lifestyle changes, such as maintaining good oral hygiene and quitting smoking. Your doctor may ask you to undergo a dental examination before you start the treatment.
  

Side Effects of Xgeva 120 mg PFS

• Xgeva 120 mg PFS has many adverse effects if it is used in the wrong way. But it varies from person to person, and if you want, you can consult your doctor regarding these adverse effects.

Most Common Side Effects of Xgeva 120 mg PFS

• • Arm or leg pain
  • Joint pain
  • Muscle or bone pain
  • Constipation,
  • Abdominal discomfort
  • Hair loss
  • Skin rash
  • Tingling, pain, or numbness that moves down your leg

Common Side Effects of Xgeva 120 mg PFS

• • Upper respiratory tract infection
  • Frequent or painful urination, blood in urine, inability to hold urine
  • Musculoskeletal
  • Severe leg or joint pain

How to Use Xgeva 120 mg PFS?

• Xgeva 120 mg PFS can be administered to you subcutaneously (under the skin) by a doctor or nurse. You should also take calcium and vitamin D supplements while being on treatment with Xgeva 120 mg Prefilled Syringe. Your doctor will determine the correct dose and duration for you, taking into account your age, body weight, and disease condition.
  

How Xgeva 120 mg PFS Works?

• Anti-bone loss injection Xgeva works to slow down bone destruction caused by cancer spreading to the bone (bone metastasis) or by giant cell tumor of bone.
  

Safety Advices Xgeva 120 mg PFS

Driving

Safe

Xgeva PFS Injection has no or negligible influence on the ability to drive and use machines.

Alcohol

Unsafe

It is generally not recommended to drink alcohol while taking Anti-bone loss injection Xgeva. It may increase the risk of liver damage. It is best to avoid alcohol or limit your alcohol consumption while taking any medication.

Kidney

Use with Caution

Xgeva 120 mg PFS should be used with caution in patients having severe kidney problems. Patients with severe kidney impairment (creatinine clearance < 30 mL/min) or receiving dialysis are at greater risk of developing hypocalcemia. Consult your doctor before receiving Xgeva 120 mg Prefilled Syringe.

Pregnancy

Unsafe

Xgeva 120 mg PFS is not recommended for use in pregnant women and women of childbearing potential not using contraception. Women should be advised not to become pregnant during and for at least 5 months after treatment with Denosumab 120 mg Injection. Seek your doctor's advice, as studies on pregnant women and animals have shown significant harmful effects on the developing baby.

Breastfeeding

Unsafe

Xgeva 120 mg PFS is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

Liver

Use with Caution

Xgeva 120 mg PFS should be used with caution in patients with liver disease. It is important that patients with liver disease closely monitor liver function while taking Anti-bone loss injection Xgeva and report any unusual symptoms or changes in liver function to their doctor. The dose of Anti-bone loss injection Xgeva may need to be adjusted in patients with liver disease.