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Actilyse 20 mg Injection
Actilyse 20 mg Injection
Prescription Required
Prescription Required

Actilyse 20 mg Injection | 1 Vial

20000.00
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Boehringer Ingelheim India Pvt Ltd
Alteplase 20 mg
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Introduction of Actilyse 20 mg Injection

Actilyse 20 mg Injection belongs to a group of medicines called thrombolytic agents. It is used to treat several conditions caused by blood clots forming within blood vessels, including, heart attacks caused by blood clots in the arteries of the heart (acute myocardial infarction), blood clots in the arteries of the lungs (acute massive pulmonary embolism), stroke caused by a blood clot in an artery of the brain (acute ischaemic stroke). Actilyse 20 mg Injection works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.

Actilyse 20 mg Injection may cause some adverse effects such as confusion, nausea, and vomiting. It has many serious side effects. The most common and serious side effect of this medicine is bleeding. Treatment with this drug can lead to bleeding in the brain (cerebral haemorrhage), extremely low blood pressure (shock), and cardiac arrest (where your heart stops beating). Your treatment may be stopped if any of these happen. Talk to your doctor about the risk of serious side effects before you are given this medicine.

Before taking the Actilyse 20 mg Injection, let your doctor know about all your sensitivities and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. If you are having any medical problems including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, intracranial conditions that may increase the risk of bleeding, bleeding diathesis, current severe uncontrolled hypertension, current intracranial haemorrhage, subarachnoid haemorrhage and history of a recent stroke. It is recommended not to take alcohol while Actilyse 20 mg Injection therapy.

Actilyse 20 mg Injection is given by a healthcare professional or nurse in the hospital or clinical setting. The most frequent adverse reactions of this therapy are bleeding and injection site reactions. Most of these side effects of Actilyse 20 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.


Uses of Actilyse 20 mg Injection

Acute Myocardial Infraction: Actilyse 20 mg Injection is used to treat acute myocardial infarction, also known as a heart attack. Actilyse 20 mg works by breaking down blood clots that are blocking the blood flow to the heart. If you experiencing symptoms of a heart attack, such as chest pain, shortness of breath, or discomfort in the upper body, it is important to seek medical attention immediately.

Pulmonary Embolism: Actilyse 20 mg Injection is used to treat pulmonary embolism, which is a condition in which a blood clot in the arteries of the lungs. If you experiencing any symptoms of Pulmonary embolism. it is important to seek medical attention immediately.

Acute Ischemic Stroke: Actilyse 20 mg Injection is used to treat acute ischemic stroke, which is a type of stroke that occurs when a blood clot blocks the blood flow to the brain. Actilyse 20 mg works by breaking down blood clots that are blocking the blood flow to the brain. If you experiencing symptoms of a stroke, such as sudden weakness or numbness on one side of the body, difficulty speaking or understanding speech or vision loss in one eye, it is important to seek medical attention immediately.


Benefits of Actilyse 20 mg Injection

Treatment of Heart attack: Actilyse 20 mg Injection dissolves harmful blood clots that cause heart attack (if they are in the heart). They also dissolve clots that form in other blood vessels. This means that blood can again start to flow freely through your body. This medicine will, therefore, reduce both the damage caused by and the risk of dying from a heart attack. The sooner the injection is given, the greater the chances of recovery.

Treatment of Ischemic stroke: Actilyse 20 mg Injection is sometimes called a “clot-buster” because it dissolves harmful blood clots that cause strokes (if they are in the brain). This helps the blood flow freely around your body thereby reducing the damage caused by and the future risk of stroke. It should be given as soon as possible after the onset of stroke.

Treatment of Pulmonary embolism: Pulmonary embolism refers to the clotting of blood in your lungs. Actilyse 20 mg Injection prevents this clot formation in your lungs. This helps the blood flow freely around your body thereby preventing a heart attack or stroke. It prevents the formation of blood clots and also prevents the existing ones from growing bigger in size. Make appropriate lifestyle changes (such as eating healthy and staying active) to maximize the effectiveness of this medicine. Follow your doctor’s instructions carefully to get maximum benefit.


Side Effects of Actilyse 20 mg Injection

Like all medicines, this Actilyse 20 mg Injection can cause side effects, although not everybody gets them.


Most Common Side Effects of Actilyse 20 mg Injection

  • Bleeding
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Nose bleeding
  • Paralysis
  • Prolonged bleeding from cuts
  • Red or dark brown urine
  • Difficulty in breathing
  • Difficulty in swallowing
  • ​Anxiety
  • Pale skin
  • Convulsion
  • Cough
  • Dilated neck veins
  • Extreme fatigue
  • Muscle spasm​


Common Side Effects of Actilyse 20 mg Injection

  • Tachycardia ( fast heartbeat )
  • Fainting
  • Slurred speech
  • Sudden loss of consciousness
  • Altered sensorium
  • Respiratory distress
  • Vision changes
  • Shallow/ Rapid breathing


How to Use Actilyse 20 mg Injection?

Actilyse 20 mg Injection is administered by a healthcare provider in a hospital or clinic setting. It is usually given as an intravenous (IV) injection or infusion. The specific dosing and administration of Actilyse 20 mg will depend on the clinical condition of the patient's age and medical history and other factors. Actilyse 20 mg Injection should be given over a period of time, usually 60 minutes for a stroke and 90 minutes for a heart attack. Closely monitor the patient's blood pressure and other vital signs during the infusion. It is important to follow your doctor's instructions carefully when using this medication.


How Actilyse 20 mg Injection Works?

Actilyse 20 mg Injection is a thrombolytic agent. It activates plasminogen, which then breaks down the blood clots. Actilyse 20 mg Injection helps to improve blood flow and can reduce the risk of damage to the brain or other organs due to a lack of blood flow.


Safety Advices Actilyse 20 mg Injection

driving
Driving
Safe

Actilyse 20 mg Injection has no or negligible influence on the ability to drive or use machines.

liver
Liver
Safe

Inform your doctor before receiving the Actilyse 20 mg Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

breastfeeding
Breastfeeding
Safe

Actilyse 20 mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

kidney
Kidney
Safe

Inform your doctor before receiving the Actilyse 20 mg Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

alcohol
Alcohol
Unsafe

It is not recommended to consume alcohol while taking Actilyse 20 mg Injection. Alcohol may increase the risk of side effects or interfere with the effectiveness of the Actilyse 20 mg. It is best to talk to your doctor or pharmacist before consuming alcohol while taking any medicine.

pregnancy
Pregnancy
Safe

Actilyse 20 mg Injection should be given to pregnant women only if the need clearly outweighs the potential risk. If you are pregnant, think you might be pregnant or are planning to have a baby, ask your doctor for advice. Your doctor will only give you Actilyse 20 mg if the possible benefit outweighs the possible risk to your baby.


References

1. Activase (Alteplase) for Injection, for Intravenous Use, Genentech, Inc, Product Leaflet

2. Actilyse (Alteplase) Powder for Injection, Boehringer Ingelheim Pty Limited, Product Leaflet

3. Actilyse Powder and Solvent for Solution for Injection and Infusion 10 Mg, 20 Mg and 50 Mg, Boehringer Ingelheim Pharma Gmbh & Co. Kg, Product Leaflet

4. Actilyse 20 Mg Powder and Solvent for Solution for Injection and Infusion, Boehringer Ingelheim (N.Z.) Limited, Product Leaflet

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