Themiset Injection
Themiset Injection
Prescription Required
Prescription Required

Themiset Injection | 5 ml in 1 Vial

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Themis Medicare Limited
Palonosetron 0.25 mg

Introduction of Themiset 0.25 mg Injection

Themiset Injection belongs to a class of drugs called serotonin receptor antagonists. It is used to prevent nausea and vomiting that can occur as a side effect of chemotherapy or surgery in adults and paediatrics. Themiset 0.25 mg works by blocking certain receptors in the brain that trigger nausea and vomiting in response to chemical signals

Themiset 0.25 mg may cause some of the common adverse effects including nausea, vomiting, headache and constipation, QT prolongation, bradycardia, fatigue, diarrhoea, indigestion or upset stomach, dizziness, and weakness. It's important to note that not everyone will experience these side effects, and some individuals might experience different or more severe reactions. If you are taking Themiset Injection and are concerned about its potential side effects, it's best to discuss them with your healthcare provider. They can provide you with personalized information and guidance based on your medical history and individual circumstances. If you experience any severe or unusual side effects while taking Themiset Injection, it's important to seek medical attention promptly.

Before taking Themiset Injection, tell your doctor about all your medical conditions, such as if you have any kidney or liver disease or any other medical problems. Many other medications may interact with Themiset 0.25 mg, so tell your doctor if you are currently using stimulants, opiates, herbal products, or medications for depression, mental disorders, Parkinson's disease, migraines, serious infections, or to treat nausea and vomiting. These drugs may interact with palonosetron and cause a serious condition called serotonin syndrome.

Themiset 0.25 mg is usually given as a slow IV injection, directly into a vein, often in your arm or hand by a trained healthcare professional. It's important to follow your healthcare provider's instructions precisely. They will determine the appropriate dosage, timing, and method of administration based on your medical condition, the type of chemotherapy or surgery you're undergoing, and other relevant factors. If you have any questions or concerns about the administration of Palonosetron or any other medication, it's recommended that you discuss them with your healthcare provider or a medical professional. They can provide you with personalized guidance and ensure that you receive the medication safely and effectively.

Uses of Themiset 0.25 mg Injection

  • Chemotherapy-induced nausea and vomiting
  • Post-operative nausea and vomiting

Benefits of Themiset 0.25 mg Injection

Themiset Injection is a medicine that is mainly used to prevent nausea and vomiting caused by chemotherapy, especially in patients undergoing cancer treatment.Themiset Injection blocks the action of chemicals in the body that can make you feel or get sick. It is used in both adults and children to prevent nausea and vomiting associated with cancer treatment such as chemotherapy or radiotherapy. This medicine can help you to recover more easily from these types of treatment. {It is also used to prevent nausea and vomiting after an operation (only in adults). Themiset Injection is injected by a doctor using the dose that is best for you, depending on the condition you are being treated for. Do not give yourself this medicine to avoid unwanted side effects.

Side Effects of Themiset 0.25 mg Injection

Like all medicines, Themiset Injection may cause side effects that do not require medical attention and which will disappear as your body adjusts to the medicine. Tell your doctor if they persist or if you're worried about them.

Most Common Side Effects of Themiset 0.25 mg Injection

  • Itching
  • Shivering
  • Trembling or shaking
  • Twitching
  • Fever
  • ​Headache
  • Pain
  • Redness
  • Constipation
  • Agitation
  • Diarrhoea
  • Lack of coordination
  • Restlessness

Common Side Effects of Themiset 0.25 mg Injection

  • Breathing difficulty
  • Confusion
  • Comma ( loss of consciousness)
  • Arrhythmias ( irregular heart beats)
  • Lightheadedness
  • Chest pain
  • Rashes

How to Use Themiset 0.25 mg Injection?

Themiset Injection is given by a healthcare professional in a hospital or clinic setting. It is usually given 30 minutes before chemotherapy or just before you are given an anaesthetic for surgery. Do not administer this Themiset 0.25 yourself.

How Themiset 0.25 mg Injection Works?

Themiset Injection is a selective serotonin receptor antagonist, specifically targeting the 5-HT3 receptors. These receptors are found in the central nervous system and the gastrointestinal tract. When certain signals are transmitted to these receptors, they can trigger a nauseous feeling and vomiting reflex. Themiset Injection works by binding to these 5-HT3 receptors and blocking their activation by serotonin, which is a neurotransmitter that can trigger nausea and vomiting signals.

Safety Advices Themiset 0.25 mg Injection


Themiset Injection may be considered safe to use in patients with liver disease. There is no dose adjustment of Themiset 0.25 mg is recommended.


Drinking alcohol while taking Themiset 0.25 is generally not recommended. It may increase the risk of liver damage. It is best to avoid alcohol or limit your alcohol intake while taking any medication.


In general, Themiset Injection is safe to use during pregnancy. Animal studies have shown little or no harm to the developing baby, but there is limited research in humans.


It is probably safe to use Themiset 0.25 mg while you are breastfeeding. The limited data available in humans suggest that the drug does not pose a significant risk to the baby.


Themiset 0.25 mg may cause dizziness, fatigue, and difficulty concentrating and coordinating, which may affect your ability to drive a vehicle safely. It is important to follow your doctor's instructions and take necessary precautions such as avoiding driving a vehicle or operating heavy machinery if you suffer from the side effects of this Themiset.


Themiset Injection may consider safe to use in patients with kidney disease. There is no dose adjustment of Themiset 0.25 mg is recommended.


1. Palonosetron (Injection), Drugs.Com, Avaliable Form

2. Palonosetron (Injection), Medline Plus.Com, Avaliable Form

3. Palonosetron (Injection), Dialymed.Com, Avaliable Form

4. Palonosetron Hydrochloride Injection, For Intravenous Use, Qilu Pharmaceutical, Product Leaflet

5. Palonosetron Hydrochloride Injection, for Intravenous Use, Fresenius Kabi, Product Leaflet

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